abstract：:The molecular mechanisms underlying entry of group B Streptococci (GBS) into human endothelial cells are not yet fully understood. This study is centered on the triggering of signaling cascade in human umbilical vein endothelial cells (HUVEC) during their interaction with different GBS serotypes/strains (type III: 803...

journal_title：International journal of molecular medicine

authors： Santos GS,Lione VO,Costa E Silva Filho F,Nagao PE

更新日期：2005-05-01 00:00:00

abstract：:The adenomatous polyposis coli gene (APC gene) originally was identified as a tumor suppressor gene in colon cancer. We reported previously that APC is mutated and/or deleted in primary oral squamous cell carcinoma (OSCC) tissues and suggested that loss of APC function contributes to carcinogenesis in the oral region....

journal_title：International journal of molecular medicine

authors： Uesugi H,Uzawa K,Kawasaki K,Shimada K,Moriya T,Tada A,Shiiba M,Tanzawa H

更新日期：2005-04-01 00:00:00

abstract：:Apoptosis induced by docetaxel that interferes with microtubule polymerization dynamics and is used clinically to treat advanced cancers, has not been fully defined in squamous cell carcinoma. In this study, apoptotic events involved in docetaxel treatment were investigated. When the human oral squamous cell carcinoma...

journal_title：International journal of molecular medicine

authors： Taniguchi T,Takahashi M,Shinohara F,Sato T,Echigo S,Rikiishi H

更新日期：2005-04-01 00:00:00

abstract：:The anti-cancer and cancer-preventive effects of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] are well documented by a variety of studies, including epidemiological, cell culture, animal, and clinical studies. While (-)-EGCG remains the most potent polyphenol in green tea, it is very unst...

journal_title：International journal of molecular medicine

authors： Landis-Piwowar KR,Kuhn DJ,Wan SB,Chen D,Chan TH,Dou QP

更新日期：2005-04-01 00:00:00

abstract：:Cerebellin (CER) is a regulatory peptide, originally isolated from rat cerebellum, which derives from the cleavage of precerebellin (Cbln), three types of which (Cbln1-3) have been identified in humans and rats. CER is also expressed in several extra-cerebellar tissues, including adrenal gland, and evidence has been p...

journal_title：International journal of molecular medicine

authors： Rucinski M,Albertin G,Spinazzi R,Ziolkowska A,Nussdorfer GG,Malendowicz LK

更新日期：2005-03-01 00:00:00

abstract：:The human adrenocortical carcinoma-derived SW-13 cell line is currently used to study the interrelationships occurring between cytokines and growth factors and endothelins (ET) and adrenomedullin (AM). SW-13 cells express either ET-1 and AM or growth factors, and several cytokines stimulate ET-1 and AM release from SW...

journal_title：International journal of molecular medicine

authors： Albertin G,Carraro G,Petrelli L,Guidolin D,Neri G,Nussdorfer GG

更新日期：2005-03-01 00:00:00

abstract：:Frizzled-1 (FZD1), FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9 and FZD10 are seven-transmembrane-type WNT receptors with extracellular Frizzled (Fz) domain. ROR1, ROR2 and MUSK are receptor-type tyrosine kinases with extracellular Fz domain, while MFRP is type II transmembrane protein with extracellular Fz domain. ...

journal_title：International journal of molecular medicine

authors： Katoh M,Katoh M

更新日期：2005-03-01 00:00:00

abstract：:Prostate cancer is among the most common tumors in industrialized nations. However, little is known about the molecular events underlying its development. In the present study we used suppressive subtraction hybridization (SSH) in combination with laser-assisted microdissection in order to compare gene expression betw...

journal_title：International journal of molecular medicine

authors： Ko Y,Hahn T,Lu H,Ma ZL,Chen J,Rothe M,Florin A,Fronhoffs S,Albers P,Sachinidis A,Vetter H,Kaminski A,Behrens P,Wellmann A,Wernert N

更新日期：2005-02-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2), a multifunctional member of the transforming growth factor (TGF)-beta, superfamily, has powerful osteoinductive effects and causes cell cycle arrest in a variety of transformed cell lines. We have observed BMP-2-induced inhibition of cell proliferation in an androgen-dependent hum...

journal_title：International journal of molecular medicine

authors： Tomari K,Kumagai T,Shimizu T,Takeda K

更新日期：2005-02-01 00:00:00

abstract：:Clinical observations and our high-density oligonucleotide microarray results demonstrated increased expression of proinflammatory chemokines after SARS-CoV infection. Here, we investigated the influence of SARS-CoV infection on CXCL8 (interleukin 8) and CXCL10 (interferon-gamma-inducible protein 10) in human intestin...

journal_title：International journal of molecular medicine

authors： Cinatl J Jr,Michaelis M,Morgenstern B,Doerr HW

更新日期：2005-02-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that is thought to mediate apoptosis. We have shown that the kinase domain of DAPK is crucial for the induction of renal tubular cell apoptosis in chronic obstructive uropathy (COU) created by unilateral ureteral ligation. DA...

journal_title：International journal of molecular medicine

authors： Yukawa K,Kishino M,Hoshino K,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Bai T,Tanaka T,Ueyama T,Ichinose M,Takeda K,Akira S,Maeda M

更新日期：2005-01-01 00:00:00

abstract：:Breast cancer accounts for 30-40% of all deaths from cancers in females. In an effort to identify tumor associated antigens that may be useful for immunotherapy, we utilized serological analysis of recombinant cDNA expression libraries (SEREX) technique to identify breast cancer-associated antigens. SEREX screening of...

journal_title：International journal of molecular medicine

authors： Qian F,Odunsi K,Blatt LM,Scanlan MJ,Mannan M,Shah N,Montgomery J,Haddad F,Taylor M

更新日期：2005-01-01 00:00:00

abstract：:Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. Many previous studies have shown that the level of platinum-DNA-adduct correlats with response to platinum-based chemotherapy. Although the mechanism of platinum resistance in vivo is not clearly underst...

journal_title：International journal of molecular medicine

authors： Altaha R,Liang X,Yu JJ,Reed E

更新日期：2004-12-01 00:00:00

abstract：:Acute renal failure (ARF) is a common disease with high morbidity and mortality. Recovery from ARF is dependent on the replacement of necrotic tubular cells with functional tubular epithelium. Recent advancement in developmental biology led to the discovery of immature mesenchymal stem cells (MSCs) in bone marrow and ...

journal_title：International journal of molecular medicine

authors： Herrera MB,Bussolati B,Bruno S,Fonsato V,Romanazzi GM,Camussi G

更新日期：2004-12-01 00:00:00

abstract：:Dideoxypetrosynol A, a polyacetylene from the sponge Petrosia sp., is known to exhibit significant selective cytotoxicity against several human tumor cell lines. In the present study, we investigated the possible mechanisms by which dideoxypetrosynol A exerts its anti-proliferative action in cultured human SK-MEL-2 sk...

journal_title：International journal of molecular medicine

authors： Choi HJ,Bae SJ,Kim ND,Jung JH,Choi YH

更新日期：2004-12-01 00:00:00

abstract：:Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor-associated periodic syndrome (TRAPS) and in patients with the autoimmune disorders, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Genomic DNA from the members o...

journal_title：International journal of molecular medicine

authors： Horiuchi T,Tsukamoto H,Mitoma H,Miyagawa H,Tamimoto Y,Yoshizawa S,Harada M,Hayashi K,Hashimura C,Oribe M,Okamura S

更新日期：2004-11-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional fermented seasoning of Japan and available throughout the world. Polysaccharides were obtained from dialysate of Shoyu, and these Shoyu polysaccharides (SPS) were examined for anti-allergic activity in vitro and in vivo. The SPS originated from partially-degraded polysaccharides of s...

journal_title：International journal of molecular medicine

authors： Kobayashi M,Matsushita H,Yoshida K,Tsukiyama R,Sugimura T,Yamamoto K

更新日期：2004-11-01 00:00:00

abstract：:ARHGAP1, ARHGAP2, ARHGAP3, ARHGAP4, ARHGAP5, ARHGAP6, ARHGAP7 (DLC1), ARHGAP8, ARHGAP9, ARHGAP10, ARHGAP12, ARHGAP13 (SRGAP1), ARHGAP14 (SRGAP2), ARHGAP15, ARHGAP17 (RICH1), ARHGAP18, ARHGAP19, ARHGAP20, ARHGAP21, ARHGAP22, ARHGAP23, ARHGAP24, ARHGAP25, ARHGAP26, STARD13 (DLC2), HA-1, GMIP, PARG1, RACGAP1, PIK3R1, PIK...

journal_title：International journal of molecular medicine

authors： Katoh Y,Katoh M

更新日期：2004-11-01 00:00:00

abstract：:In our previous study, the proliferation rate of esophageal squamous cell carcinoma cell lines, which poorly expressed p21Waf1, was found to be regulated by p21Waf1 gene transfection using adenovirus vector. In the present study, in order to examine the effect of p21Waf1 gene therapy in esophageal cancer, we used gene...

journal_title：International journal of molecular medicine

authors： Tanaka Y,Fujii T,Yamana H,Kato S,Morimatsu M,Shirouzu K

更新日期：2004-10-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for vascular diseases. Findings indicate that Alzheimer disease (AD) and vascular dementia (VaD) may have common risk factors and/or pathogene...

journal_title：International journal of molecular medicine

authors： Folin M,Baiguera S,Conconi MT,Di Liddo R,De Carlo E,Parnigotto PP,Nussdorfer GG

更新日期：2004-10-01 00:00:00

abstract：:To estimate the genetic and dietary factors influencing bone mineral density (BMD) in young adults, a total of 53 healthy volunteers (HV) (age 20.89+/-1.34), from whom informed consent was obtained, answered a questionnaire on dietary factors and had DNA from peripheral blood mononuclear cells analyzed for single nucl...

journal_title：International journal of molecular medicine

authors： Otsuki T,Sakaguchi H,Hatta E,Hatayama T,Hatada S,Miura Y,Takata-Tomokuni A,Hyodoh F,Tomomitsu T,Fukunaga M,Katsuyama H

更新日期：2004-10-01 00:00:00

abstract：:Osteosarcoma (OS), a malignant bone neoplasia in childhood, has poor prognosis if metastases appear in the lung. A novel therapeutic approach could consist in a gene therapeutic treatment of OS metastases. However, if promiscuous viral vectors are applied for the delivery of potentially toxic transgenes, their misdeli...

journal_title：International journal of molecular medicine

authors： Pollmann A,Kabisch H,Block A,Müller J,Hellwinkel OJ

更新日期：2004-10-01 00:00:00

abstract：:We determined whether the expression of VEGF-A and -C and their receptors, Flt-1 and Flt-4, are associated with primary tumor size, regional lymph node metastasis, distant metastasis and prognosis in patients with tongue carcinoma. The expression of VEGF-A and -C, and their receptors, Flt-1 and Flt-4, in biopsy specim...

journal_title：International journal of molecular medicine

authors： Tanigaki Y,Nagashima Y,Kitamura Y,Matsuda H,Mikami Y,Tsukuda M

更新日期：2004-09-01 00:00:00

abstract：:Evidence has been recently provided that beacon, an ubiquitin-like protein overexpressed in the hypothalamus of Israeli sand rat, is also expressed in several endocrine glands of the Wistar rat, including adrenal cortex. Moreover, it has been shown that the in vivo administration of beacon[47-73] (hereinafter, beacon)...

journal_title：International journal of molecular medicine

authors： Ziolkowska A,Carraro G,Rebuffat P,Spinazzi R,Nussdorfer GG,Rucinski M,Malendowicz LK

更新日期：2004-09-01 00:00:00

abstract：:p63, a recently identified member of the p53 gene family, plays an important role in human tissue functions. We examined the pattern of p63 expression in human esophageal squamous cell carcinomas including early-stage cancers, and its clinicopathological significance. Immunoreactivity for p63 was detected in 96.9% (63...

journal_title：International journal of molecular medicine

authors： Hara T,Kijima H,Yamamoto S,Kenmochi T,Kise Y,Tanaka H,Chino O,Shimada H,Takazawa K,Tanaka M,Inokuchi S,Makuuchi H

更新日期：2004-08-01 00:00:00

abstract：:Phellinus linteus is a well-known Oriental medicinal fungus that has various biological activities, including immunomodulatory and anti-tumor activities, the mechanisms of which are poorly understood. In the present study, we investigated the effects of mycelium extracts of P. linteus (MEPL) on the growth of human neu...

journal_title：International journal of molecular medicine

authors： Choi YH,Huh MK,Ryu CH,Choi BT,Jeong YK

更新日期：2004-08-01 00:00:00

abstract：:Aberrant methylation of promoter CpG islands is known to be responsible for the alteration and silencing of genes in cancer. The data presented here describes that the CpG methylations of ERalpha and ERbeta are found in breast cancer tissues, and methylation exerts a considerable effect on gene silencing, investigated...

journal_title：International journal of molecular medicine

authors： Kim SJ,Kim TW,Lee SY,Park SJ,Kim HS,Chung KW,Lee ES,Kang HS

更新日期：2004-08-01 00:00:00

abstract：:Zinc has been shown to have an inhibitory effect on osteoclastic bone resorption in vitro. This study was undertaken to determine whether the inhibitory action of zinc on osteoclastogenesis is related to receptor activator of NF-kappaB ligand (RANKL), which plays a pivotal role in differentiation from pre-osteoclasts ...

journal_title：International journal of molecular medicine

authors： Yamaguchi M,Uchiyama S

更新日期：2004-07-01 00:00:00

abstract：:The adaptive response of skeletal muscle fibres depends on a variety of biological factors including loading conditions and neuromuscular activity. An extreme type of atrophy-inducing change in contractile activity is represented by the physical disconnection between the motor nerve and its respective fibre unit. Sinc...

journal_title：International journal of molecular medicine

authors： Donoghue P,Ribaric S,Moran B,Cebasek V,Erzen I,Ohlendieck K

更新日期：2004-06-01 00:00:00

abstract：:Leptin is a 147-amino acid adipose tissue-secreted hormone, which acts via several subtypes of receptors, the main and better known variants of which are named Ob-Ra and Ob-Rb. Structure-activity relationship studies pointed out the importance of the N-terminal and C-terminal amino-acid sequences 22-115 and 116-166, r...

journal_title：International journal of molecular medicine

authors： Malendowicz LK,Gorska T,Tortorella C,Nowak M,Majchrzak M,Spinazzi R,Nussdorfer GG,Nowak KW

更新日期：2004-06-01 00:00:00

abstract：:Glioblastoma is one of the most radioresistant tumors. Exposure of cells to ionizing radiation leads to formation of reactive oxygen species (ROS) that are associated with radiation-induced cytotoxicity. ROS scavengers, therefore, are one of the important factors in protecting cells against ROS injury during ionizing ...

journal_title：International journal of molecular medicine

authors： Lee HC,Kim DW,Jung KY,Park IC,Park MJ,Kim MS,Woo SH,Rhee CH,Yoo H,Lee SH,Hong SI

更新日期：2004-06-01 00:00:00

abstract：:Autologous chondrocyte implantation (ACI) relies on the use of cultured cells. However, the biosynthetic profile of cultured chondrocytes is shown to be altered during in vitro expansion. The purpose of this study therefore, was to examine the cellular phenotype of chondrocytes cultured for ACI and to determine the ap...

journal_title：International journal of molecular medicine

authors： Zheng MH,King E,Kirilak Y,Huang L,Papadimitriou JM,Wood DJ,Xu J

更新日期：2004-05-01 00:00:00

abstract：:In the absence of antibodies specific for lymphatic vessels, analysis of lymphatic vessels within different tissues has been widely performed with light microscopic and, most importantly, electron microscopic techniques. In regard to lymphatic vessels in the ocular globe and the periocular structures, controversy rema...

journal_title：International journal of molecular medicine

authors： Fogt F,Zimmerman RL,Daly T,Gausas RE

更新日期：2004-05-01 00:00:00

abstract：:Proteasome inhibitors, like MG132, can exert cell growth inhibitory and apoptotic effects in different tumor types. The apoptotic mechanism of these compounds involves the activation of the effector caspases. beta-catenin, also an oncogene, represents one of the substrates of these proteases, but the consequences of i...

journal_title：International journal of molecular medicine

authors： Cervello M,Giannitrapani L,La Rosa M,Notarbartolo M,Labbozzetta M,Poma P,Montalto G,D'Alessandro N

更新日期：2004-05-01 00:00:00

abstract：:Death-associated protein kinase (DAPK) is a Ca2+/calmodulin-dependent serine/threonine kinase that has been implicated as a positive mediator of apoptosis. However, little is known about the involvement of DAPK in the apoptosis associated with several pathological states, except for cancer. Here, DAPK-mutant mice were...

journal_title：International journal of molecular medicine

authors： Yukawa K,Hoshino K,Kishino M,Mune M,Shirasawa N,Kimura A,Tsubota Y,Owada-Makabe K,Tanaka T,Ichinose M,Maeda M,Takeda K,Akira S

更新日期：2004-04-01 00:00:00

abstract：:We have studied an age-related impairment in angiogenesis and evaluated the effect of overexpressing VEGF in this situation. Polyvinyl alcohol sponges were implanted subcutaneously into aged (24-month), adult (12-month), and young (2-month) rats. Blood vessel ingrowth and proliferative activity in the sponges were ass...

journal_title：International journal of molecular medicine

authors： Wang H,Keiser JA,Olszewski B,Rosebury W,Robertson A,Kovesdi I,Gordon D

更新日期：2004-04-01 00:00:00

abstract：:Von Hippel-Lindau (VHL) syndrome is an autosomal dominant neoplastic disorder characterized by hemangioblastomas of the central nervous system and retina, renal cell carcinomas, pheochromocytoma, and islet cell tumors. This syndrome is closely related with the VHL, a tumor suppressor gene, implying that loss of functi...

journal_title：International journal of molecular medicine

authors： Iida K,Okimura Y,Takahashi K,Inomata S,Iguchi G,Kaji H,Chihara K

更新日期：2004-03-01 00:00:00

abstract：:We have studied how benzyl-N-acetyl-alpha-D-galactosaminide, O-glycosylation inhibitor, affects the polymorphism and shedding of membrane-bound MUC1 mucin, and change in adhesive properties of cancer cells. In endometrial adenocarcinoma cells (Ishikawa line), high molecular weight MUC1 mucin was shed from cellular mem...

journal_title：International journal of molecular medicine

authors： Porowska H,Paszkiewicz-Gadek A,Anchim T,Wolczynski S,Gindzienski A

更新日期：2004-03-01 00:00:00

abstract：:Lipoprotein(a) [Lp(a)] is an atherogenic and prothrombotic molecule formed by the covalent binding of the highly polymorphic apolipoprotein(a) [apo(a)] to apoprotein B-100 of LDL. High Lp(a) concentrations are a recognized genetic risk factor for coronary heart disease (CHD) and have been shown to be related with a fa...

journal_title：International journal of molecular medicine

authors： Peros E,Geroldi D,D'Angelo A,Falcone C,Montagna L,Carabela M,Emanuele E

更新日期：2004-02-01 00:00:00

abstract：:We described that two different murine mammary adenocarcinoma cell lines, LM3 and LM2 constitutively expressed muscarinic acetylcholine receptors (mAchR). We here demonstrate, by competitive binding experiments with the tritiated muscarinic antagonist quinuclidinyl benzilate that M2 subtype predominates in both tumor ...

journal_title：International journal of molecular medicine

authors： Español AJ,Sales ME

更新日期：2004-02-01 00:00:00